Therefore difficult, if not impossible, to interpret among Reliably for D9-THC when given exogenously, except atĭ -THC from an equal volume of its vehicle (below) theremaining animals (n=10) were trained to discriminate D9-Ĭhemdoses that decrease response rates significantly and are Of South Carolina, 1512 Pendleton Street, Columbia SC 29208, USAĬannabinoid receptor ligess: (J.B. Universitesi, Mugla, Turkey.scriminative stimulus effects of All rights reserved.Į-mail addr1 Present address: Psikoloji Bflqmq, Fen Edebiyat Fakqltesi, Mugla Introduction bind to the cannabinoid receptor substitute completely for9Increasing the selectivity of theīehavioral Pharmacology Laboratory, Department of Psychology, UniĪbstract0091-3057/$ - see front matter D 2004 Elsevier Inc. Keywords: Drug discrimination Drug-other D9-Tetrahydrocannabinol (THC) Anandamide (R)-methanandamide Pentobarbital Phencyclidine (PCP) Morphineġ. For this reason, the D9-THC-other training procedure might be described as being more selective than the commonlyused drugno drug procedure.ĭ 2004 Elsevier Inc. Regardless of the level of D9-THC lever responding, all drugs except diazepam substituted less in the D9-THC-other than inthe control group. In substitution (generalization) tests, a highdose of anandamide, which also severely decreased response rate, substituted partially in both the control and the D9-THC-other group (R)-methanandamide, an analog of anandamide which is metabolized more slowly, substituted completely for D9-THC in the control,and partially in the D9-THC-other group neither pentobarbital nor diazepam substituted completely for D9-THC under any experimentalcondition. Acquisition of the D9-THC-other discrimination was rapid (38 days) and did not differ significantly from that of a group ofbcontrolQ animals trained to discriminate D9-THC (3.2 mg/kg) from its vehicle (33 days). Safe to conclude that there are no differences in the stimulusIn an attempt to increase the selectivity of the discriminative stimulus effects of D9-tetrahydrocannabinol (THC), rats were trained todiscriminate 3.2 mg/kg of this compound from a group of botherQ drugs consisting of morphine (3.2 mg/kg), PCP (2.5 mg/kg), andvehicle. These compounds from appropriate vehicles, it is probably Since D9-THC also substitutes for CP 55,490 or WIN55,212 when animals are trained to discriminate either of (Compton et al., 1992), cannabinol (Jarbe and Hiltunen,ġ988), and D8-tetrahydrocannabinol (Jarbe and McMillan,1979). (responses/min): these include, but are not limited to variousġ1-hydroxy metabolites of THC (Jarbe and McMillan,ġ979), CP 55,940 (Gold et al., 1992), (+)-WIN 55,212 Potencies of subjective effects in humans (Balster andĪnd do so at doses that do not also disrupt rate of responding
Ination (DD) procedures that are highly correlated with Psychoactive cannabinoids with potencies in drug discrim. Tive stimulus effects of D9-THC seem to be relativelyspecific that is, they generalize to other, naturally occurring Humans these include hypokinesia, hypothermia, andĪntinociception (Pertwee, 1988).
That are not related to its marijuana-like properties in Tel.: +1 8 fax: +1 8.Delta-9-tetrahydrocannabinol (D -THC) produces a widevariety of pharmacological effects in rats and other animals Pharmacology, Biochemistry and Behav* Corresponding author. The discriminative stimulus effects of anandamide, the
Potencies (Perio et al., 1996 Wiley et al., 1995). In addition, compounds thatĭ -THC when this substance is used as the training drugĮffects of various cannabinoids other than their relative
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